Textbook of Biochemistry with Clinical. Correlations, Sixth Edition. Thomas M. Devlin, Editor, John Wiley & Sons, Inc.,. Hoboken, NJ, 1, pp., $, Thomas M. Devlin — 4th ed. . In this fourth edition of Textbook of Biochemistry With Clinical Correlations, the contributors have with six chapters on topics that comprise Physiological Chemistry, including cytochrome P enzymes and. Textbook of Biochemistry with Clinical Correlations, Sixth Edition. Thomas M. Devlin, ed. Hoboken, NJ: Wiley-Liss, John Wiley & Sons, , pp., $
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by Devlin, Thomas M. biochemistry biochemistry Textbook of Biochemistry - For Medical Students, 6th Edition Textbook Equity Edition Vol 2. -JDFOTF. Textbook of Biochemistry with Clinical Correlations (6th Edition). Edited by Thomas M. Devlin; Wiley‐Liss, Hoboken, New Jersey, , Request PDF on ResearchGate | Textbook of Biochemistry with Clinical Correlations, Sixth Edition. Thomas M. Devlin, ed. Hoboken, NJ: Wiley-Liss, John Wiley.
Amir Hosein Salmanpour. Citation Tools. Gorham, M. Tools Request permission Export citation Add to favorites Track citation. These answers might have been better placed elsewhere in the volume, where they might be less accessible. Clinical Biochemistry.
The book focuses very specifically on eukaryotic biochemistry, with emphasis on mammalian systems, because of the importance of understanding biochemistry as it pertains to human disease. This textbook is designed to fulfill the requirements of most upper level undergraduate and graduate level courses in biochemistry and physiological chemistry. The text is broken down into 5 main sections that cover the areas of macromolecular structure, transmission of information including translational and transcriptional events, protein function, metabolic pathways and their control, and physiological processes.
These 5 sections are broken down further to generate a total of 28 chapters, each of which is written by an expert in that particular field; taken together, the chapters cover the entire area of eukaryote biochemistry. New sections have been introduced that cover the recently expanded areas of signal transduction, the cell cycle, apoptosis, and cancer. Each chapter is interspersed with several clinical correlations that are related to that particular section.
For instance, the chapter covering the process of DNA repair describes the DNA-repair disease xeroderma pigmentosum in sufficient detail that the reader begins to get a feel for how the basic biochemistry relates to the disease. Sufficient references are provided so that the interested student can look further into the literature on the diseases.
By introducing the student to a better understanding of the biochemical mechanisms of the diseases, these correlations may also lead to defining rational therapeutic interventions. In my own specialist area of lipid metabolism, deficiencies of the fatty acid metabolizing acyl-CoA dehydrogenases are defined as a group of diseases that may be potentially treatable with a combination of dietary manipulation and prevention of fasting, because these are essentially diseases of fasting intolerance.
At the end of each chapter, there is a quiz, so the student may self-evaluate as a learning guide. The answers to the quizzes are also provided at the end of each chapter. These answers might have been better placed elsewhere in the volume, where they might be less accessible.
In the rapidly progressing field of biochemistry, the bibliographies of all of the chapters have been updated since the last edition, to maintain continuity.
The textbook has ample and well-colored diagrams throughout that are of the highest quality. The diagrams provide a very important aid to understanding what are frequently complicated mechanisms and pathways.
This is an excellent teaching volume, which could readily be used not only by undergraduates and graduate students but also by fellows in clinical chemistry training programs. Skip to main content. Michael J.
Previous Next. Back to top. In this issue. To understand the principles and applications of regulatory concepts it is better to see how a single system operates, then one can carry over to other systems. Many texts also tend to gloss over tissue differences.
Dr Devlin's book is refreshing in consistently pointing out these differences. Thus discussion of glycolysis includes a lovely figure illustrating glucose metabolism in RBCs, brain, muscle, adipose ceils, and liver parenchymal ceils. Knowledge of these tissue variations gives a qualitatively different and expanded perspective of the metabolism of the whole organism, versus the naive view which can arise from many texts.
The instructor can also use some of the 'Clinical Correlations' to demonstrate aspects of regulation, tissue variability etc. My students were amazed to see how the interrelatedness of biochemical systems leads to the final consequences of Fructose Intolerance.
Thus chapter 14 discusses tissue interrelationships during various metabolic states, while chapters 15 and 16 discuss the biochemistry of various hormones, including their biosynthesis and modes of action.
DNA, RNA, protein biosynthesis and genetic regulation are given a thorough and, to the extent possible in these rapidlydeveloping fields, up-to-date treatment in four chapters.
Both prokaryotic and eukaryotic systems are treated, a necessary inconsistency compared to the rest of the book, but a requirement to give an adequate treatment of these topics. These first 20 chapters constitute an essentially complete biochemistry text.
However there are an additional six chapters covering some aspects of physiological chemistry: These chapters vary considerably in biochemical content. There is little new here, but it is convenient. On the other hand there is much new biochemistry in the chapter on iron and heme metabolism. Though I found the information in these chapters interesting, I must ask whether they are necessary in a text already pages long without this material.
And much of it will, after all, appear in other required coursework of the medical or biology student. The editor suggests that this book could serve as an upper division or graduate-level biochemistry text.
For students in these courses the book has some advantages and some major deficiencies. To me the major advantages are its clear presentation of the biochemistry of a single organism, particularly regulation and control, and the constant attention to correlating particular pathways to specific tissues.
I feel that most students are better served by gaining an integrated understanding of the workings of a single complete system, than they are by being inundated by scattered facts dealing with a myriad of organisms. I also feel it is important for students to realize that tissues in eukaryotes are specialized, in biochemistry as well as function, and that biochemical integration often comes only at the whole organism level. I was also impressed with the various authors' concern that purported processes have been shown to occur under physiological conditions and at physiological concentrations.
How often in the past have we created fallacious models based on unrealistic in vitro experiments? The major deficiencies of this text are a complete lack of plant biochemistry, including photosynthesis, and the various important pathways lacking in humans, such as essential amino acid biosynthesis and vitamin biosynthesis. For the nonmedical student this is important stuff. Most students, including medical students, would also benefit from problems at the ends of the chapters.
Overall I recommend this book as a medical school text and as an excellent reference. It has been very useful to me in preparing my own lectures for undergraduates.
Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks.
Thomas Devlin and his twentyone co-authors aimed to produce a textbook for medical students in which biochemical events at the cellular level are related to physiological processes in the whole animal and the relevance of topics to disease problems is emphasised throughout.
These correlations cover a considerable range, describing the biochemistry of disease states, biochemical actions of antibiotics and drugs and use of biochemical tests in diagnosis. Often the same clinical condition, eg diabetes, thalassaemia, gout, is used to illustrate different points in separate chapters. This approach is attractive and for the most part these correlations succeed, but there are some surprising omissions and others are rather contrived.
Besides the clinical correlations there are other useful features particularly welcome for medical s t u d e n t s - the sections on metabolic interrelationships, nutrition, metabolism of individual tissues, pH regulation, gas transport and genetic engineering. The basic biochemistry is sound and well-written, except for one or two chapters, and there is adequate crossreferencing.
However, while this is an attractive book for medical students there are defects. Generally there is too much detail for British preclinical courses.
The photographs and diagrams black-and-white only compare unfavourably with competing biochemistry books and the Index could be better for such a complex book where many topics cut across several sections.
If the proposed paper-bound edition January is very substantially cheaper, then it will be worth buying. S J Higgins himself into the sort of muddle considered reprehensible in an undergraduate biochemistry student. The next paragraph tells us that a plot of reaction rate against substrate concentration allows the rate constants to be determined, but unfortunately the method of achieving this useful and remarkable feat is not given. I have concentrated on the small part of the book that is concerned with what I know most about, because I feel that if a book cannot give a clear and accurate account of what I know already it is unwise to trust what it says about anything else.
Perhaps the author is stronger on thermodynamics than on kinetics, but I doubt it. It is not obvious, for example, that he has noticed that most biological processes occur at constant pressure in the liquid phase, rather than at constant volume in the gas phase.
So when enthalpy and the Gibbs energy are mentioned at all they are treated as an afterthought and not as quantities that are central to the whole subject. The book is proudly described as a 'second, corrected and updated edition', though it contains virtually no references to modern experimental work in biology or biochemistry and refers, for example, to the unit membrane model of Danielli and Davson as 'generally accepted'.
What the book must have been like before it was updated beggars the imagination. Springer-Verlag, Berlin.